[科研工作] 医治肺癌的抗血管扩张及杀肿瘤药研究,主要负责人,美国国家卫生研究院/美国国家癌症研究院, 1R43CA130506-01A1 (2007-2008) 医治神经胶质瘤的独特的cMet和Tie2抑制剂研究,主要负责人,美国国家卫生研究院/美国国家癌症研究院, 1R43CA128164-01 (2007-2008) 医治神经胶质瘤的抗血管扩张及抗肿瘤药研究,主要负责人,美国国家卫生研究院/美国国家癌症研究院,1R43CA96077-01 (2002-2004) 治疗肝纤维症的肝细胞生长因子模拟化合物研究,负责人,美国国家卫生研究院,1R43DK64455-01 (2003-2004) 外部贫血的肝细胞生长因子转移研究,负责人,美国国家卫生研究院 2R44HL062048-02A1 (2002-2004) 新型抗前列腺癌一类新药的临床前研究,课题负责人,国家科技重大专项“重大新药创制”2011ZX09102-001-05 (2011-2013),目前已经结题 新型抗前列腺癌一类新药的临床前研究,课题负责人,江苏省科技支撑计划(社会发展)BE2011687 (2011-2014),目前已经结题 新型抗前列腺癌一类新药的临床前研究,课题负责人,苏州市科技计划 ZXY2012030 (2012-2014),目前已经结题 PI3K/mTOR靶向抗癌一类新药研发,课题负责人,科技部中小企业创新基金 12C26213202433(2012-2014),目前已经结题 新药研发:1.Hedgehog抑制剂肿瘤药理研究 2.IDO抑制剂瘤药理研究 Zhou T, Xu W.D., Xu C.L., Gao X, Hou J.G., Ren S.C., Yang B, Wei G.L., Sun Y., Chen CY, Guo C.X., Tong Y., Karl Zhou, Sun Y.H. A first-in-human phase 1 study of proxalutamide (GT0918), a dual MOA androgen receptor blocker in patients with advanced CRPC. 2017.35.15_suppl.e16511 Journal of Clinical Oncology Tong, Y., Chen CY., Wu J., Zhang HH.,(2013) Discovery of potent androgen receptor antagonists for treating CRPC and AR-Positive breast cancer,Cancer Research Volume 73, Issue 8, Supplement 1 ,2460. Tong, Y., Chen CY., Wu J., Zhang HH.,(2014) Preclinical Studies and Clinical Plan for Proxalutamide (GT0918), A Potent Androgen Receptor Pathway Inhibitor, Cancer Research Volume 74, Issue 19,614 Tong, Y., Song, W., and Crystal, R.G. (2001) Combined intratumoral injection of bone marrow-derived dendritic cells and systemic chemotherapy to treat pre-existing murine tumors. Cancer Research 61(20):7530-7535. Song, W., Tong, Y., Carpenter, H., Kong, H.L., Rafii, S., Granstein, R., Moore, M.A.S., and Crystal, R.G. (2000). Induction of persistent, antigen-specific, therapeutic antitumor immunity by dendritic cells genetically modified with an adenoviral vector to express a model tumor antigen. Human Gene Therapy, 7(24):2080-2086. Banerjee, D., Tong, Y., Liu-Chen, X., Capiaux, G., Ercikan-Abali, E.A., Takebe, N., O'Conner, O.A., and Bertino, J.R. (1999). Protection of bone marrow cells from toxicity of chemotherapeutic agents targeted toward thymidylate synthase by transfer of mutant forms of human thymidylate synthase cDNA. Prog. Exp. Tumor Res. 36:107-114. Sapse, D.S., Tong, Y., Bertino, J.R., and Sapse, A.M. (1999) Ab initio studies of some amino acid residue complexes with 4-mercaptopyridine as a model for Thymitaq (AG337), an inhibitor of thymidylate synthase. Cancer Invest. 17(6):396-401. Tong, Y., Liu-Chen, X., Ercikan-Abali, E.A., Zhao, S.C., Banerjee, D., Maley, F., and Bertino, J.R. (1998) Probing the folate binding site of human thymidylate synthase by site-directed mutagenesis. Generation of mutants that confer resistance to raltitrexed, Thymitaq and BW1843U89. J. Biol. Chem., 273:31209-31214. Tong, Y., Liu-Chen, X., Ercikan-Abali, E.A., Banerjee, D., and Bertino, J.R. (1998) Isolation and characterization of Thymitaq (AG337) and 5-fluoro-2-deoxyuridylate-resistance mutants of human thymidylate synthase from ethlmethanesulfonate-exposed human sarcoma HT1080 cells. J. Biol. Chem., 273:11611-11618. Ercikan-Abali, E.A., Mineishi, S., Tong, Y., Waltham, M.C., Banerjee, D., Nakahara, S., Sadelain, M., and Bertino, J.R. (1996). Active site directed double mutants of dihydrofolate reductase. Cancer Research 56:4142-4145. Chou, T.C., Motzer, R.J., Tong, Y., and Bosl, G.J. (1994). Computerized quantitation of synergism and antagonism of taxol, topotecan, and cisplain against human teratocarcinoma cell growth: a rational approach to clinical protocol design. J. Natl. Cancer Intl. 86:1517-1709. Banerjee, D., Zhao, S.C., Tong, Y., Steinherz, J., Gritsman, K., and Bertino, J.R. (1994). Transfection of a nonactive site mutant murine DHFR cDNA (the tryptophan 15 mutant) into Chinese hamster ovary and mouse marrow progenitor cells imparts MTX resistance in vitro. Cancer Gene Therapy 1:181-184. Tong, Y., Jin, X.L., Liu, Y.Q., Xu, X.J., and Tang, Y.Q. (1991). Synthesis and crystal structure of the azido dinuclear copper(II) cryptate of macrocyclic ligands [Cu2(N3)2(C16H38N6)](ClO4)2. Acta Chimica Sinica(Ch.) 49:48-52. Jin, X.L., Tong, Y., Xu, X.J., and Tang, Y.Q. (1991). Synthesis and crystal structure of the binucleating macrocyclic monohydroxo-bridged dicopper(II) complex [Cu2(OH)(ClO4)(C16H38N6)](ClO4)2CHCl3. J. Inorg. Chem.(Ch.) 7:69-75. Jin, X.L., Tong, Y., Xu, X.J., and Tang, Y.Q. (1991). The synthesis and crystal structure of the thiocuanato dinuclear copper(II) complex of macrocyclic ligand [Cu2(SCN)3(C16H38N6)]2(ClO4)2. Acta Physico-Chimica Sinica(Ch.) 7:323-328. Jin, X.L., Jiang, Y.J., and Tong, Y. (1989). Synthesis and crystal structure of (diethylenetriamine)(acetate) zinc perchlorate. J. Struct. Chem.(Ch.) 8:229-231. Tong, Y., Jin, X.L., Xu, X.J., and Tang, Y.Q. (1988). The superoxide dismutase and its model chemistry (Review). Journal of Biochemical Pharmaceutical(Ch.) 44(2):23-28. 工作经历: 1999至2003年在美国北岸长岛犹太卫生系统任高级研究科学家,实验室主任 1999至2006年在美国阿尔伯特-爱因斯坦医学院任副教授 2000至2006年在美国费恩斯坦医药研究院任副研究员 2002至2008在美国Angion药业公司任高级研究科学家,副总裁 2008至现在在美国Kintor药业公司任总裁 2009至现在在苏州开拓药业有限公司任总经理